It took me a long time to upgrade to Blender 2.6x as I was really used to my good old Blender. A way to make friends with new software is to explore possibilities as much as possible; here, some of the cool stuff I found (may include old stuff I never noticed before).
Don't be afraid of scripts!
Blender includes many useful, reliable, user friendly scripts. Fearlessly, go to user preferences > add-ons and try it out; next to each script, links to online docs are provided.
Two scripts I always enable:
- Dynamic spacebar menu. This will especially please blender-sauruses as it brings back the spacebar function from Blender 2.4x and earlier: